Welcome to the PHO Research Lab Ghent
Our mission
The mission of the PHO Research Lab Ghent is to improve outcomes and long-term quality-of-life of children diagnosed with cancer, through clinical-translational laboratory research, participating in clinical studies and collecting relevant biomaterials (biobanking).
Latest publication
Leijnen F and Lammens T (2026). Decoding Notch1: from T-cell development guardian to driver of pediatric T-cell lymphoblastic lymphone. Int J Mol Sci 27 (4): 2083. DOI: 10.3390/ijms.27042083.
This review synthesizes current insights into the molecular landscape of pediatric T-LBL, with a focus on the biological and clinical implications of NOTCH1 mutations and translocations. Furthermore, we examine emerging approaches to therapeutically exploit aberrant NOTCH1 signaling for the more precise and effective treatment of this disease and formulate outstanding research questions.
A schematic representation of the multidomain architecture of the NOTCH1 protein. EGF, epidermal growth factor; LNRs, Lin12–Notch repeats; HD, heterodimerization domain; TM, transmembrane domain; RAM, RBP-Jκ-associated module domain; ANK, Ankyrin repeats; NLS, nuclear localization signal; TAD, transactivation domain; PEST, proline–glutamate–serine–threonine-rich domain. Created with BioRender.com